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Some Metamask users report experiencing USB connectivity issues when trying to connect to Ledger devices.
Firefox users: Firefox 114 broke U2F compatibility - disrupting the ability to connect Ledger or any other hardware wallets to MetaMask. Please use other browsers which support U2F or WebHID connection method type (eg. Chrome, Brave).
Additionally, make sure to enable HID devices in your Chrome settings as seen in the picture below:
To access this setting, you can click the following link in Chrome:
Using a different browser extension
The Ledger help center contains guides for how to set these up safely:
If, after checking these things, you still encounter issues, make sure you keep Metamask up to date in the event that a fix is rolled out.