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Some Metamask users report experiencing USB connectivity issues when trying to connect to Ledger devices.
Firefox users: Firefox 112 disabled U2F - disrupting the ability to connect Ledger to MetaMask. There is a workaround that lets you re-enable U2F support in Firefox documented here.
Chrome users: Ensure WebHID is selected in MetaMask > Settings > Advanced.
Additionally, make sure to enable HID devices as seen in the picture below:
To access this setting, you can click the following link in Chrome:
Using a different browser extension
So far, no issues have been reported on other web3 browser extensions such as Ledger Extension, Rabby, or Taho.
The Ledger help center contains guides for how to set these up safely:
How to install Ledger Extension
Set up and use Rabby wallet to access your Ledger Ethereum (ETH) account
If, after checking these things, you still encounter issues, make sure you keep Metamask up to date in the event that a fix is rolled out.
You can follow us on Twitter at @Ledger_Support for updates.